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Article

C-Raf is required for the initiation of lung cancer by K-Ras(G12D).

Cancer discovery - 1 Jul 2011

Karreth Florian A, Frese Kristopher K, DeNicola Gina M, Baccarini Manuela, Tuveson David A

Abstract excerpt

The Ras/Raf/MEK/ERK (extracellular signal-regulated kinase) pathway is primarily responsible for mitogenesis in metazoans, and mutational activation of this pathway is common in cancer. A variety of selective chemical inhibitors directed against the mitogen-activated protein kinase pathway are now available for clinical investigation and thus the determination of the importance of each of the kinases in...

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Identifiers

PMID: 22043453
DOI: 10.1158/2159-8290.CD-10-0044
PMCID: PMC3203527

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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