Article
C-Raf is required for the initiation of lung cancer by K-Ras(G12D).
Cancer discovery - 1 Jul 2011
Karreth Florian A, Frese Kristopher K, DeNicola Gina M, Baccarini Manuela, Tuveson David A
Abstract excerpt
The Ras/Raf/MEK/ERK (extracellular signal-regulated kinase) pathway is primarily responsible for mitogenesis in metazoans, and mutational activation of this pathway is common in cancer. A variety of selective chemical inhibitors directed against the mitogen-activated protein kinase pathway are no...
Topics
- Animals
- Cell Growth Processes
- Cell Transformation, Neoplastic
- Epithelial Cells
- Extracellular Signal-Regulated MAP Kinases
- Fibroblasts
- Lung
- Lung Neoplasms
- MAP Kinase Signaling System
- Mesenchymal Stem Cells
- Mice
- Mice, 129 Strain
- Mitogen-Activated Protein Kinases
- Mutation
- Proto-Oncogene Proteins B-raf
- Proto-Oncogene Proteins c-raf
- Transformation, Genetic
- ras Proteins