Article
Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization.
Molecular cell - 22 Dec 2005
Garnett Mathew J, Rana Sareena, Paterson Hugh, Barford David, Marais Richard
Abstract excerpt
The protein kinase B-RAF is mutated in approximately 7% of human cancers. Most mutations are activating, but, surprisingly, a small number have reduced kinase activity. However, the latter can still stimulate cellular signaling through the MEK-ERK pathway because they activate the related family member C-RAF. We examine the mechanism underlying C-RAF activation by B-RAF. We show that C-RAF is activated in the...
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