Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation loop phosphorylation regulates B-Raf in vivo and transformation by B-Raf mutants.

The EMBO journal - 18 Jan 2016

Köhler Martin, Röring Michael, Schorch Björn, Heilmann Katharina, Stickel Natalie, Fiala Gina J, Schmitt Lisa C, Braun Sandra, Ehrenfeld Sophia, Uhl Franziska M, Kaltenbacher Thorsten, Weinberg Florian, Herzog Sebastian, Zeiser Robert, Schamel Wolfgang W, Jumaa Hassan, Brummer Tilman

Abstract excerpt

Despite being mutated in cancer and RASopathies, the role of the activation segment (AS) has not been addressed for B-Raf signaling in vivo. Here, we generated a conditional knock-in mouse allowing the expression of the B-Raf(AVKA) mutant in which the AS phosphoacceptor sites T599 and S602 are replaced by alanine residues. Surprisingly, despite producing a kinase-impaired protein, the Braf(AVKA) allele does not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Proliferation
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Activation

Share to MAP Kinase Signaling System

Share to Mitogen-Activated Protein Kinase Kinases

Share to Models, Biological

Share to Phosphorylation

Share to Proto-Oncogene Proteins B-raf

Source

Open in PubMed Open full text

Identifiers

PMID: 26657898
DOI: 10.15252/embj.201592097
PMCID: PMC4718462

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation loop phosphorylation regulates B-Raf in vivo and transformation by B-Raf mutants.PMID 26657898Read ↗

The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway.Semantic proximity Read ↗

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF.Semantic proximity Read ↗

Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts.Semantic proximity Read ↗

Discovery of Raf Family Is a Milestone in Deciphering the Ras-Mediated Intracellular Signaling PathwaySemantic proximity Read ↗

Deciphering the RAS/ERK pathway in vivo.Semantic proximity Read ↗

Identification and Characterization of a B-Raf Kinase α-Helix Critical for the Activity of MEK Kinase in MAPK Signaling.Semantic proximity Read ↗

MEK-1 activates C-Raf through a Ras-independent mechanism.Semantic proximity Read ↗

Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling.Semantic proximity Read ↗

RAF protein-serine/threonine kinases: structure and regulation.Semantic proximity Read ↗

Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation.Semantic proximity Read ↗

A Raf-1 mutant that dissociates MEK/extracellular signal-regulated kinase activation from malignant transformation and differentiation but not proliferation.Semantic proximity Read ↗

Divergent effects of intrinsically active MEK variants on developmental Ras signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.