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Article

Early differential responses elicited by BRAFV600E in adult mouse models.

Cell death & disease - 10 Feb 2022

Bosso Giuseppe, Lanuza-Gracia Pablo, Piñeiro-Hermida Sergio, Yilmaz Merve, Serrano Rosa, Blasco Maria A

Abstract excerpt

The BRAF gene is frequently mutated in cancer. The most common genetic mutation is a single nucleotide transition which gives rise to a constitutively active BRAF kinase (BRAFV600E) which in turn sustains continuous cell proliferation. The study of BRAFV600E murine models has been mainly focused on the role of BRAFV600E in tumor development but little is known on the early molecular impact of BRAFV600E expression...

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Identifiers

PMID: 35145078
DOI: 10.1038/s41419-022-04597-z
PMCID: PMC8831492

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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