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Article

Introgressed chromosome 2 quantitative trait loci restores aldosterone regulation and reduces response to salt in the stroke-prone spontaneously hypertensive rat.

Journal of hypertension - 1 Oct 2014

Sampson Amanda K, Mohammed Dashti, Beattie Wendy, Graham Delyth, Kenyon Christopher J, Al-Dujaili Emad A S, Guryev Victor, Mcbride Martin W, Dominiczak Anna F

Abstract excerpt

BACKGROUND: The genetic contribution to salt-sensitivity in hypertension remains unclear. We have previously identified a quantitative trait locus on chromosome 2 in stroke-prone spontaneously hypertensive rats (SHRSPs) responsible for an increase in SBP in response to a salt challenge. This response is blunted in the congenic SHRSP strain with the Wistar-Kyoto (WKY) chromosome 2 region (10 cM) introgressed...

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Identifiers

PMID: 25084306
DOI: 10.1097/HJH.0000000000000300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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