Article
Exaggerated response to cold stress in a congenic strain for the quantitative trait locus for blood pressure.
Journal of hypertension - 1 Nov 2004
Cui Zong-Hu, Ikeda Katsumi, Kawakami Kohei, Gonda Tatsuo, Masuda Junichi, Nabika Toru
Abstract excerpt
OBJECTIVE: Stroke-prone spontaneously hypertensive rats (SHRSP) are known to have sympathetic hyperactivity to various stimuli. In the search for 'intermediate phenotypes' inferring the function of hypertension genes, the present study assessed responsiveness to cold stress in a congenic strain derived from SHRSP/Izm and Wistar-Kyoto/Izm (WKY/Izm). DESIGN: A congenic strain, WKYpch1.0, was established by 10...
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