Article
Dissection of chromosome 18 blood pressure and salt-sensitivity quantitative trait loci in the spontaneously hypertensive rat.
Hypertension (Dallas, Tex. : 1979) - 1 Sept 2009
Johnson Michelle D, He Liqun, Herman Daniel, Wakimoto Hiroko, Wallace Caroline A, Zidek Vaclav, Mlejnek Petr, Musilova Alena, Simakova Miroslava, Vorlicek Jaroslav, Kren Vladimir, Viklicky Ondrej, Qi Nathan R, Wang Jiaming, Seidman Christine E, Seidman Jonathan, Kurtz Theodore W, Aitman Timothy J, Pravenec Michal
Abstract excerpt
Hypertension in humans and experimental models has a strong hereditary basis, but identification of causative genes remains challenging. Quantitative trait loci (QTLs) for hypertension and salt sensitivity have been reported on rat chromosome 18. We set out to genetically isolate and prioritize genes within the salt-sensitivity and hypertension QTLs on the spontaneously hypertensive rat (SHR) chromosome 18 by...
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