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Article

Refined mapping of a hypertension susceptibility locus on rat chromosome 12.

Hypertension (Dallas, Tex. : 1979) - 1 Oct 2014

Prisco Sasha Z, Prokop Jeremy W, Sarkis Allison B, Yeo Nan Cher, Hoffman Matthew J, Hansen Colin C, Jacob Howard J, Flister Michael J, Lazar Jozef

Abstract excerpt

Previously, we found that transferring 6.1 Mb of salt-sensitive (SS) chromosome 12 (13.4-19.5 Mb) onto the consomic SS-12(BN) background significantly elevated mean arterial pressure in response to an 8% NaCl diet (178±7 versus 144±2 mm Hg; P<0.001). Using congenic mapping, we have now narrowed the blood pressure locus by 86% from a 6.1-Mb region containing 133 genes to an 830-kb region (chr12:14.36-15.19 Mb)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 25001272
DOI: 10.1161/HYPERTENSIONAHA.114.03550
PMCID: PMC4162822

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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