Article
Genetic determinants of metabolic syndrome components in the stroke-prone spontaneously hypertensive rat.
Journal of hypertension - 1 Dec 2005
Strahorn Pamela, Graham Delyth, Charchar Fadi J, Sattar Naveed, McBride Martin W, Dominiczak Anna F
Abstract excerpt
OBJECTIVE: The metabolic syndrome is a complex multifactorial disease, which results from interactions between genes on multiple chromosomes and environmental factors. Animal models may facilitate genetic analysis of complex phenotypes by allowing complete control of environmental conditions and the ability to produce designer strains. METHODS: Stroke-prone spontaneously hypertensive (SHRSP) and Wistar-Kyoto...
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