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Article

A twofold genetic increase of ACE expression has no effect on the development of spontaneous hypertension.

American journal of hypertension - 1 Feb 2008

Nassar Ibrahim, Schulz Angela, Bernardy Claudia, Garrelds Ingrid M, Plehm Ralph, Huber Matthias, Danser A H Jan, Kreutz Reinhold

Abstract excerpt

BACKGROUND: To study the regulation of a naturally occurring genetic variant of high angiotensin-converting enzyme (ACE) gene (Ace in rat) expression, i.e., the Ace allele of the normotensive Wistar-Kyoto (WKY) rat, in the hypertensive background of stroke-prone spontaneously hypertensive (SHRSP) rats. METHODS: We analyzed a congenic strain termed SHRSP.WKY-Ace derived from SHRSP in which a chromosomal fragment...

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Source

Identifiers

PMID: 18174884
DOI: 10.1038/ajh.2007.38

Genes

ACE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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