Article
Slow repair of lipid peroxidation-induced DNA damage at p53 mutation hotspots in human cells caused by low turnover of a DNA glycosylase.
Nucleic acids research - 1 Aug 2014
Woodrick Jordan, Gupta Suhani, Khatkar Pooja, Sarangi Sanchita, Narasimhan Ganga, Trehan Akriti, Adhikari Sanjay, Roy Rabindra
Abstract excerpt
Repair of oxidative stress- and inflammation-induced DNA lesions by the base excision repair (BER) pathway prevents mutation, a form of genomic instability which is often observed in cancer as 'mutation hotspots'. This suggests that some sequences have inherent mutability, possibly due to sequence-related differences in repair. This study has explored intrinsic mutability as a consequence of sequence-specific...
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