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Article

Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells.

Nature - 11 Jan 2018

Garaycoechea Juan I, Crossan Gerry P, Langevin Frédéric, Mulderrig Lee, Louzada Sandra, Yang Fentang, Guilbaud Guillaume, Park Naomi, Roerink Sophie, Nik-Zainal Serena, Stratton Michael R, Patel Ketan J

Abstract excerpt

Haematopoietic stem cells renew blood. Accumulation of DNA damage in these cells promotes their decline, while misrepair of this damage initiates malignancies. Here we describe the features and mutational landscape of DNA damage caused by acetaldehyde, an endogenous and alcohol-derived metabolite. This damage results in DNA double-stranded breaks that, despite stimulating recombination repair, also cause...

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Identifiers

PMID: 29323295
DOI: 10.1038/nature25154
PMCID: PMC6047743

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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