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Article

Dynamic Processing of a Common Oxidative DNA Lesion by the First Two Enzymes of the Base Excision Repair Pathway.

Journal of molecular biology - 5 Mar 2021

Raper Austin T, Maxwell Brian A, Suo Zucai

Abstract excerpt

Base excision repair (BER) is the primary pathway by which eukaryotic cells resolve single base damage. One common example of single base damage is 8-oxo-7,8-dihydro-2'-deoxoguanine (8-oxoG). High incidence and mutagenic potential of 8-oxoG necessitate rapid and efficient DNA repair. How BER enzymes coordinate their activities to resolve 8-oxoG damage while limiting cytotoxic BER intermediates from propagating...

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Identifiers

PMID: 33450252
DOI: 10.1016/j.jmb.2021.166811
PMCID: PMC8225441

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