Article
Generation of mutator mutants during carcinogenesis.
DNA repair - 7 Mar 2006
Venkatesan Ranga N, Bielas Jason H, Loeb Lawrence A
Abstract excerpt
Mutations are rare in normal cells. In contrast, multiple mutations are characteristic in most tumors. Previously we proposed a "mutator phenotype" hypothesis to explain how pre-cancer cells may acquire large number of mutations during carcinogenesis. Here we extend the "mutator phenotype" hypothesis considering recently discovered biochemical activities whose aberrant expression may result in genome-wide random...
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