Article
Germ line variants of human N-methylpurine DNA glycosylase show impaired DNA repair activity and facilitate 1,N6-ethenoadenine-induced mutations.
The Journal of biological chemistry - 20 Feb 2015
Adhikari Sanjay, Chetram Mahandranauth A, Woodrick Jordan, Mitra Partha S, Manthena Praveen V, Khatkar Pooja, Dakshanamurthy Sivanesan, Dixon Monica, Karmahapatra Soumendra K, Nuthalapati Nikhil K, Gupta Suhani, Narasimhan Ganga, Mazumder Raja, Loffredo Christopher A, Üren Aykut, Roy Rabindra
Abstract excerpt
Human N-methylpurine DNA glycosylase (hMPG) initiates base excision repair of a number of structurally diverse purine bases including 1,N(6)-ethenoadenine, hypoxanthine, and alkylation adducts in DNA. Genetic studies discovered at least eight validated non-synonymous single nucleotide polymorphisms (nsSNPs) of the hMPG gene in human populations that result in specific single amino acid substitutions. In this...
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