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Article

Concordance of hydrogen peroxide-induced 8-oxo-guanine patterns with two cancer mutation signatures of upper GI tract tumors.

Science advances - 3 Jun 2022

Jin Seung-Gi, Meng Yingying, Johnson Jennifer, Szabó Piroska E, Pfeifer Gerd P

Abstract excerpt

Oxidative DNA damage has been linked to inflammation, cancer, and aging. Here, we have mapped two types of oxidative DNA damage, oxidized guanines produced by hydrogen peroxide and oxidized thymines created by potassium permanganate, at a single-base resolution. 8-Oxo-guanine occurs strictly dependent on the G/C sequence context and shows a pronounced peak at transcription start sites (TSSs). We determined the...

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Identifiers

PMID: 35658030
DOI: 10.1126/sciadv.abn3815
PMCID: PMC9166614

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