Article

Consensus DNA Inhibits p53 Aggregation but Fails to Rescue Mutants

2025-07-26

Abstract excerpt

The tumor suppressor p53 plays a crucial role in regulating gene expression under cellular stress. Somatic mutations to its DNA-binding domain are common in lethal cancers and lead to lost regulatory function and pathological hallmarks, such as misfolded p53 aggregates and amyloid-like fibrils. Despite decades of these observations, the molecular determinants driving p53 aggregation and its role in cancer incidenc...

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Literature Corpus work: 50c40d26-b707-553e-a04c-8c9d160e5dac
DOI: 10.1101/2025.07.24.665437

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