Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sequence context effects of replication of Fapy•dG in three mutational hot spot sequences of the p53 gene in human cells.

DNA repair - 1 Dec 2021

Bacurio Jan Henric T, Yang Haozhe, Naldiga Spandana, Powell Brent V, Ryan Benjamin J, Freudenthal Bret D, Greenberg Marc M, Basu Ashis K

Abstract excerpt

Fapy•dG and 8-OxodGuo are formed in DNA from a common N7-dG radical intermediate by reaction with hydroxyl radical. Although cellular levels of Fapy•dG are often greater, its effects on replication are less well understood than those of 8-OxodGuo. In this study plasmid DNA containing Fapy•dG in three mutational hotspots of human cancers, codons 248, 249, and 273 of the p53 tumor suppressor gene, was replicated in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Adducts
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Replication

Share to Furans

Share to Genes, p53

Share to Kinetics

Share to Pyrimidines

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 34464900
DOI: 10.1016/j.dnarep.2021.103213
PMCID: PMC8616820

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sequence context effects of replication of Fapy•dG in three mutational hot spot sequences of the p53 gene in human cells.PMID 34464900Read ↗

8-Oxo-2'-deoxyguanosine Replication in Mutational Hot Spot Sequences of the p53 Gene in Human Cells Is Less Mutagenic than That of the Corresponding Formamidopyrimidine.Semantic proximity Read ↗

DNA sequence context greatly affects the accuracy of bypass across an ultraviolet light 6-4 photoproduct in mammalian cells.Semantic proximity Read ↗

Mechanisms of mutagenesis induced by DNA lesions: multiple factors affect mutations in translesion DNA synthesis.Semantic proximity Read ↗

Unexpected non-Hoogsteen-based mutagenicity mechanism of FaPy-DNA lesions.Semantic proximity Read ↗

Mutagenesis mechanism of the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine.Semantic proximity Read ↗

Slow repair of lipid peroxidation-induced DNA damage at p53 mutation hotspots in human cells caused by low turnover of a DNA glycosylase.Semantic proximity Read ↗

Mutations at G:C base pairs predominate after replication of peroxyl radical-damaged pSP189 plasmids in human cells.Semantic proximity Read ↗

A switch between DNA polymerases δ and λ promotes error-free bypass of 8-oxo-G lesionsSemantic proximity Read ↗

Involvement of specialized DNA polymerases in mutagenesis by 8-hydroxy-dGTP in human cells.Semantic proximity Read ↗

Biochemical and photochemical mechanisms that produce different UV-induced mutation spectra.Semantic proximity Read ↗

Multiple biochemical properties of the p53 molecule contribute to activation of polymerase iota-dependent DNA damage tolerance.Semantic proximity Read ↗

Biochemical analysis of H2O2-induced mutation spectra revealed that multiple damages were involved in the mutational process.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.