Article
Interferon regulatory factor-5 deficiency ameliorates disease severity in the MRL/lpr mouse model of lupus in the absence of a mutation in DOCK2.
PloS one - 1 Jan 2014
Yasuda Kei, Watkins Amanda A, Kochar Guneet S, Wilson Gabriella E, Laskow Bari, Richez Christophe, Bonegio Ramon G, Rifkin Ian R
Abstract excerpt
Interferon regulatory factor 5 (IRF5) polymorphisms are strongly associated with an increased risk of developing the autoimmune disease systemic lupus erythematosus. In mouse lupus models, IRF5-deficiency was shown to reduce disease severity consistent with an important role for IRF5 in disease pathogenesis. However these mouse studies were confounded by the recent demonstration that the IRF5 knockout mouse line...
Topics
- Animals
- Autoantibodies
- B-Cell Activating Factor
- CD4-Positive T-Lymphocytes
- Disease Models, Animal
- GTPase-Activating Proteins
- Guanine Nucleotide Exchange Factors
- Immunoglobulin Isotypes
- Interferon Regulatory Factors
- Kidney Diseases
- Lupus Erythematosus, Systemic
- Mice