Article
IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2010
Richez Christophe, Yasuda Kei, Bonegio Ramon G, Watkins Amanda A, Aprahamian Tamar, Busto Patricia, Richards Rocco J, Liu Chih Long, Cheung Regina, Utz Paul J, Marshak-Rothstein Ann, Rifkin Ian R
Abstract excerpt
Polymorphisms in the transcription factor IFN regulatory factor 5 (IRF5) are strongly associated in human genetic studies with an increased risk of developing the autoimmune disease systemic lupus erythematosus. However, the biological role of IRF5 in lupus pathogenesis has not previously been tested in an animal model. In this study, we show that IRF5 is absolutely required for disease development in the...
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