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Article

Exacerbated Autoimmunity in the Absence of TLR9 in MRL. <i>Faslpr</i> Mice Depends on <i>Ifnar1</i>

7 Mar 2013

Abstract excerpt

TLR9 suppresses TLR7-driven pathogenesis in the MRL.Fas(lpr) murine model of systemic lupus erythematosus, but the mechanisms by which TLR7 promotes and TLR9 prevents disease in this and other lupus models remain unclear. Type I IFNs (IFN-I) have also been implicated in the pathogenesis of lupus both in patients and in several murine models of disease, but their role in MRL.Fas(lpr) mice is controversial. Using...

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Identifiers

PMID: 23467932
DOI: 10.4049/jimmunol.1203525

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