Article
Role for interferon regulatory factors in autoimmunity.
Joint bone spine - 1 Dec 2010
Richez Christophe, Barnetche Thomas, Miceli-Richard Corinne, Blanco Patrick, Moreau Jean-François, Rifkin Ian, Schaeverbeke Thierry
Abstract excerpt
Interferon regulatory factors (IRFs) were first identified during studies of type I interferons. Since then, many investigations have established that IRFs are involved in regulating the innate immune response, the development of various immune cell types, and carcinogenesis. Several genetic studies have identified genetic variants, most notably IRF5, associated with an increased risk of autoimmune disease. The...
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