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Article

Regulation and role of the transcription factor IRF5 in innate immune responses and systemic lupus erythematosus

29 May 2018

Abstract excerpt

The transcription factor interferon regulatory factor-5 (IRF5) plays an important role in innate immune responses via the TLR-MyD88 (Toll-like receptor - myeloid differentiation primary response 88) pathway. IRF5 is also involved in the pathogenesis of the autoimmune disease systemic lupus erythematosus (SLE). Recent studies have identified new regulators, both positive and negative, which act on IRF5 activation...

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PMID: 29860420
DOI: 10.1093/intimm/dxy032

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