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Article

Spontaneous mutation of the Dock2 gene in Irf5-/- mice complicates interpretation of type I interferon production and antibody responses.

Proceedings of the National Academy of Sciences of the United States of America - 10 Apr 2012

Purtha Whitney E, Swiecki Melissa, Colonna Marco, Diamond Michael S, Bhattacharya Deepta

Abstract excerpt

Genome-wide studies have identified associations between polymorphisms in the IFN regulatory factor-5 (Irf5) gene and a variety of human autoimmune diseases. Its functional role in disease pathogenesis, however, remains unclear, as studies in Irf5(-/-) mice have reached disparate conclusions regarding the importance of this transcription factor in type I IFN production and antibody responses. We identified a...

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Share to Antibody Formation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to GTPase-Activating Proteins

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Source

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Identifiers

PMID: 22431588
DOI: 10.1073/pnas.1118155109
PMCID: PMC3326475

Genes

DOCK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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