Article
Phenotype and function of B cells and dendritic cells from interferon regulatory factor 5-deficient mice with and without a mutation in DOCK2.
International immunology - 1 May 2013
Yasuda Kei, Nündel Kerstin, Watkins Amanda A, Dhawan Tania, Bonegio Ramon G, Ubellacker Jessalyn M, Marshak-Rothstein Ann, Rifkin Ian R
Abstract excerpt
Interferon regulatory factor 5-deficient (IRF5 (-/-) ) mice have been used for many studies of IRF5 biology. A recent report identifies a mutation in dedicator of cytokinesis 2 (DOCK2) as being responsible for the abnormal B-cell development phenotype observed in the IRF5 (-/-) line. Both dedicator of cytokinesis 2 (DOCK2) and IRF5 play important roles in immune cell function, raising the issue of whether immune...
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