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Article

B cell–intrinsic Myd88 regulates disease progression in murine lupus

12 Sept 2023

Abstract excerpt

Nucleic acid-specific Toll-like receptors (TLRs) have been implicated in promoting disease pathogenesis in systemic lupus erythematosus (SLE). Whether such TLRs mediate disease onset, progression, or both remains undefined; yet the answer to this question has important therapeutic implications. MyD88 is an essential adaptor that acts downstream of IL-1 family receptors and most TLRs. Both global and B...

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PMID: 37787782
DOI: 10.1084/jem.20230263

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