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Article

IRF4 deficiency abrogates lupus nephritis despite enhancing systemic cytokine production.

Journal of the American Society of Nephrology : JASN - 1 Aug 2011

Lech Maciej, Weidenbusch Marc, Kulkarni Onkar P, Ryu Mi, Darisipudi Murthy Narayana, Susanti Heni Eka, Mittruecker Hans-Willi, Mak Tak W, Anders Hans-Joachim

Abstract excerpt

The IFN-regulatory factors IRF1, IRF3, IRF5, and IRF7 modulate processes involved in the pathogenesis of systemic lupus and lupus nephritis, but the contribution of IRF4, which has multiple roles in innate and adaptive immunity, is unknown. To determine a putative pathogenic role of IRF4 in lupus, we crossed Irf4-deficient mice with autoimmune C57BL/6-(Fas)lpr mice. IRF4 deficiency associated with increased...

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Identifiers

PMID: 21742731
DOI: 10.1681/ASN.2010121260
PMCID: PMC3148699

Genes

TNF

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