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Article

Interferon regulatory factor 5 is critical for the development of lupus in MRL/lpr mice.

Arthritis and rheumatism - 1 Mar 2011

Tada Yoshifumi, Kondo Seiji, Aoki Shigehisa, Koarada Syuichi, Inoue Hisako, Suematsu Rie, Ohta Akihide, Mak Tak W, Nagasawa Kohei

Abstract excerpt

OBJECTIVE: Interferon regulatory factor 5 (IRF-5) is a transcription factor that mediates intracellular signals activated by engagement of Toll-like receptors (TLRs). IRF5 polymorphisms are associated with an increased or decreased risk of systemic lupus erythematosus (SLE) in various human populations, but the precise role of IRF5 in SLE development is not fully understood. This study was undertaken to examine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21305501
DOI: 10.1002/art.30183

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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