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Article

Monoallelic IRF5 deficiency in B cells prevents murine lupus

1 Jul 2021

Abstract excerpt

Gain-of-function polymorphisms in the transcription factor IFN regulatory factor 5 (IRF5) are associated with an increased risk of developing systemic lupus erythematosus. However, the IRF5-expressing cell type(s) responsible for lupus pathogenesis in vivo is not known. We now show that monoallelic IRF5 deficiency in B cells markedly reduced disease in a murine lupus model. In contrast, similar reduction of IRF5...

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PMID: 34197340
DOI: 10.1172/jci.insight.141395

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