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Article

Distinct regulation of murine lupus susceptibility genes by the IRF5/Blimp-1 axis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2012

Panchanathan Ravichandran, Liu Hongzhu, Liu Hongqi, Fang Chee-Mun, Erickson Loren D, Pitha Paula M, Choubey Divaker

Abstract excerpt

Genome-wide association studies have identified lupus susceptibility genes such as IRF5 and PRDM1 (encoding for IFN regulatory factor 5 [IRF]5 and Blimp-1) in the human genome. Accordingly, the murine Irf5 and Prdm1 genes have been shown to play a role in lupus susceptibility. However, it remains unclear how IRF5 and Blimp-1 (a transcriptional target of IRF5) contribute to lupus susceptibility. Given that the...

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Source

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Identifiers

PMID: 22116829
DOI: 10.4049/jimmunol.1102311
PMCID: PMC3244553

Genes

PRDM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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