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Article

High resolution melting analysis: a rapid and accurate method to detect CALR mutations.

PloS one - 1 Jan 2014

Bilbao-Sieyro Cristina, Santana Guillermo, Moreno Melania, Torres Laura, Santana-Lopez Gonzalo, Rodriguez-Medina Carlos, Perera María, Bellosillo Beatriz, de la Iglesia Silvia, Molero Teresa, Gomez-Casares Maria Teresa

Abstract excerpt

BACKGROUND: The recent discovery of CALR mutations in essential thrombocythemia (ET) and primary myelofibrosis (PMF) patients without JAK2/MPL mutations has emerged as a relevant finding for the molecular diagnosis of these myeloproliferative neoplasms (MPN). We tested the feasibility of high-resolution melting (HRM) as a screening method for rapid detection of CALR mutations. METHODS: CALR was studied in...

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Source

Open in PubMed Open full text

Identifiers

PMID: 25068507
DOI: 10.1371/journal.pone.0103511
PMCID: PMC4113452

Genes

CALR
JAK2
MPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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