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A Comparison of Two Molecular Methods for Detecting CALR Mutations in Myeloproliferative Neoplasms.

Clinical laboratory - 1 Sept 2021

Chan Tzu-Hsien, Wang Yen-Yun, Chen Chih-Chieh, Huang Wen-Li, Lin I-Yen, Er Tze-Kiong

Abstract excerpt

BACKGROUND: Myeloproliferative neoplasms (MPN) are hematopoietic disorders characterized by abnormal proliferation of the myeloid lineage. Three classic subtypes are polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). These disorders are well known for their association with the JAK2 V617F mutation, in addition to mutations in MPL exon 10, and JAK2 exon 12. CALR mutations were...

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PMID: 34542973
DOI: 10.7754/Clin.Lab.2021.201201

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