Article
Calreticulin mutations in myeloproliferative neoplasms and new methodology for their detection and monitoring.
Annals of hematology - 1 Mar 2015
Chi Jianxiang, Manoloukos Menelaos, Pierides Chryso, Nicolaidou Vicky, Nicolaou Katerina, Kleopa Maria, Vassiliou George, Costeas Paul
Abstract excerpt
The diagnosis of the BCR-ABL-negative myeloproliferative neoplasms (MPN), namely polycythemia vera, essential thombocythemia and primary myelofibrosis has relied significantly on the detection of known causative mutations in the JAK2 or MPL genes, which account for the majority of MPN patients. However, around 30 % of patients with MPN, primarily essential thombocythemia and primary myelofibrosis, lack mutations...
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