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Article

Genetic Variant Detection in the CALR gene using High Resolution Melting Analysis.

Journal of visualized experiments : JoVE - 26 Aug 2020

Pajič Tadej, Belčič Mikič Tanja, Podgornik Helena, Klun Jurka, Šućurović Sandra, Zver Samo, Sever Matjaz

Abstract excerpt

High resolution melting analysis (HRM) is a powerful method for genotyping and genetic variation scanning. Most HRM applications depend on saturating DNA dyes that detect sequence differences, and heteroduplexes that change the shape of the melting curve. Excellent instrument resolution and special data analysis software are needed to identify the small melting curve differences that identify a variant or...

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PMID: 32925885
DOI: 10.3791/61642

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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