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Article

Calreticulin Mutations in Myeloproliferative Neoplasms: Comparison of Three Diagnostic Methods.

PloS one - 1 Jan 2015

Park Ji-Hye, Sevin Margaux, Ramla Selim, Truffot Aurélie, Verrier Tiffany, Bouchot Dominique, Courtois Martine, Bas Mathilde, Benali Sonia, Bailly François, Favre Bernardine, Guy Julien, Martin Laurent, Maynadié Marc, Carillo Serge, Girodon François

Abstract excerpt

Calreticulin (CALR) mutations have recently been reported in 70-84% of JAK2V617F-negative myeloproliferative neoplasms (MPN), and this detection has become necessary to improve the diagnosis of MPN. In a large single-centre cohort of 298 patients suffering from Essential Thrombocythemia (ET), the JAK2V617F, CALR and MPL mutations were noted in 179 (60%), 56 (18.5%) and 13 (4.5%) respectively. For the detection of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26501981
DOI: 10.1371/journal.pone.0141010
PMCID: PMC4621046

Genes

CALR
MPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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