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Article

Rapid and sensitive detection of CALR exon 9 mutations using high-resolution melting analysis.

Clinica chimica acta; international journal of clinical chemistry - 2 Feb 2015

Lim Ken-Hong, Lin Huan-Chau, Chen Caleb Gon-Shen, Wang Wei-Ting, Chang Yu-Cheng, Chiang Yi-Hao, Lin Ching-Sung, Su Nai-Wen, Su Ying-Wen, Lin Johnson, Chang Yi-Fang, Chang Ming-Chih, Hsieh Ruey-Kuen, Kuo Yuan-Yeh, Chou Wen-Chien

Abstract excerpt

BACKGROUND: Somatic CALR exon 9 mutations have recently been identified in patients with JAK2/MPL-unmutated myeloproliferative neoplasm, and have become an important clonal marker for the diagnosis of essential thrombocythemia (ET) and primary myelofibrosis. In the present study, we sought to use high-resolution melting analysis (HRMA) as a screening method for the detection of CALR mutations. METHODS: 32...

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Source

Identifiers

PMID: 25447704
DOI: 10.1016/j.cca.2014.11.011

Genes

CALR
JAK2
MPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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