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Article

Simultaneous screening for JAK2 and calreticulin gene mutations in myeloproliferative neoplasms with high resolution melting.

Clinica chimica acta; international journal of clinical chemistry - 1 Nov 2016

Matsumoto Nariyoshi, Mori Sayaka, Hasegawa Hiroo, Sasaki Daisuke, Mori Hayato, Tsuruda Kazuto, Imanishi Daisuke, Imaizumi Yoshitaka, Hata Tomoko, Kaku Norihito, Kosai Kousuke, Uno Naoki, Miyazaki Yasushi, Yanagihara Katsunori

Abstract excerpt

INTRODUCTION: Recently, novel calreticulin (CALR) mutations were discovered in Janus kinase 2 (JAK2) non-mutated myelofibrosis (PMF) and essential thrombocythemia (ET) cases, with a frequency of 60-80%. We examined clinical correlations and CALR mutation frequency in our myeloproliferative neoplasms (MPN) cases, and introduce an effective test method for use in clinical practice. METHODS: We examined 177 samples...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27693531
DOI: 10.1016/j.cca.2016.09.023

Genes

JAK2
CALR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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