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Article

Frequent CALR exon 9 alterations in JAK2 V617F-mutated essential thrombocythemia detected by high-resolution melting analysis

20 Mar 2015

Abstract excerpt

Essential thrombocythemia (ET) is a clonal hematopoietic stem cell neoplasm and one of the classic BCL-ABL1 -negative chronic myeloproliferative neoplasm (MPN), which also includes polycythemia vera and primary myelofibrosis (PMF). 1 Recently, two seminal studies discovered a high frequency of somatic calreticulin ( CALR ) mutations in patients with JAK2 / MPL -unmutated ET and PMF. 2 , 3 The pattern of most CALR...

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PMID: 25794131
DOI: 10.1038/bcj.2015.21

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