Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of phenotype and outcome in essential thrombocythemia with CALR or JAK2 mutations.

Haematologica - 1 Jul 2015

Al Assaf Carla, Van Obbergh Florence, Billiet Johan, Lierman Els, Devos Timothy, Graux Carlos, Hervent Anne-Sophie, Emmerechts Jan, Tousseyn Thomas, De Paepe Pascale, Papadopoulos Petros, Michaux Lucienne, Vandenberghe Peter

Abstract excerpt

The JAK2 V617F mutation, the thrombopoietin receptor MPL W515K/L mutation and calreticulin (CALR) mutations are mutually exclusive in essential thrombocythemia and support a novel molecular categorization of essential thrombocythemia. CALR mutations account for approximately 30% of cases of essential thrombocythemia. In a retrospective study, we examined the frequency of MPL and CALR mutations in JAK2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calreticulin
Share to Janus Kinase 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukocyte Count

Share to Platelet Count

Share to Primary Myelofibrosis

Share to Receptors, Thrombopoietin

Share to Survival Analysis

Share to Thrombocythemia, Essential

Source

Open in PubMed Open full text

Identifiers

PMID: 25934766
DOI: 10.3324/haematol.2014.118299
PMCID: PMC4486223

Genes

CALR
JAK2
MPL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of phenotype and outcome in essential thrombocythemia with CALR or JAK2 mutations.PMID 25934766Read ↗

[Clinical and biological features of patients with essential thrombocythaemia according to their mutational status JAK2 or CALR: Single-center study of 40 patients and review of the literature].Semantic proximity Read ↗

JAK2 or CALR mutation status defines subtypes of essential thrombocythemia with substantially different clinical course and outcomes.Semantic proximity Read ↗

Frequencies, clinical characteristics, and outcome of somatic CALR mutations in JAK2-unmutated essential thrombocythemia.Semantic proximity Read ↗

A rare CALR variant mutation and a review of CALR in essential thrombocythemia.Semantic proximity Read ↗

Impact of calreticulin mutations on clinical and hematological phenotype and outcome in essential thrombocythemia.Semantic proximity Read ↗

JAK2 V617F, MPL, and CALR Mutations in Korean Patients with Essential Thrombocythemia and Primary Myelofibrosis.Semantic proximity Read ↗

A meta-analysis comparing clinical characteristics and outcomes in CALR-mutated and JAK2V617F essential thrombocythaemia.Semantic proximity Read ↗

A rare CALR variant mutation and efficient peginterferon alfa-2a response in a patient with essential thrombocythemia.Semantic proximity Read ↗

Analysis of CALR-mutated essential thrombocythemia as a distinct disease entity compared with JAK2 V617F-mutated and triple-negative patients.Semantic proximity Read ↗

Clinical Manifestation of Calreticulin Gene Mutations in Essential Thrombocythemia without Janus Kinase 2 and MPL Mutations: A Chinese Cohort Clinical Study.Semantic proximity Read ↗

Type 1 versus Type 2 calreticulin mutations in essential thrombocythemia: a collaborative study of 1027 patients.Semantic proximity Read ↗

CALR mutation burden in essential thrombocythemia and disease outcome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.