Article
Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat.
Cell - 1 Aug 2013
Atanur Santosh S, Diaz Ana Garcia, Maratou Klio, Sarkis Allison, Rotival Maxime, Game Laurence, Tschannen Michael R, Kaisaki Pamela J, Otto Georg W, Ma Man Chun John, Keane Thomas M, Hummel Oliver, Saar Kathrin, Chen Wei, Guryev Victor, Gopalakrishnan Kathirvel, Garrett Michael R, Joe Bina, Citterio Lorena, Bianchi Giuseppe, McBride Martin, Dominiczak Anna, Adams David J, Serikawa Tadao, Flicek Paul, Cuppen Edwin, Hubner Norbert, Petretto Enrico, Gauguier Dominique, Kwitek Anne, Jacob Howard, Aitman Timothy J
Abstract excerpt
Large numbers of inbred laboratory rat strains have been developed for a range of complex disease phenotypes. To gain insights into the evolutionary pressures underlying selection for these phenotypes, we sequenced the genomes of 27 rat strains, including 11 models of hypertension, diabetes, and insulin resistance, along with their respective control strains. Altogether, we identified more than 13 million...
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