Article
High-resolution identity by descent mapping uncovers the genetic basis for blood pressure differences between spontaneously hypertensive rat lines.
Circulation. Cardiovascular genetics - 1 Jun 2011
Bell Rebecca, Herring Stacy M, Gokul Nisha, Monita Monique, Grove Megan L, Boerwinkle Eric, Doris Peter A
Abstract excerpt
BACKGROUND: The recent development of a large panel of genome-wide single nucleotide polymorphisms (SNPs) provides the opportunity to examine genetic relationships between distinct SHR lines that share hypertension but differ in their susceptibility to hypertensive end-organ disease. METHODS AND RESULTS: We compared genotypes at nearly 10,000 SNPs obtained for the hypertension end-organ injury-susceptible...
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