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Article

Long-read whole-genome sequencing of SHR rat substrains with distinct substance use phenotypes.

Mammalian genome : official journal of the International Mammalian Genome Society - 22 Dec 2025

Abdurahaman Adil, Lemen Paige M, Kantak Kathleen M, Baskin Britahny M, Bryant Camron D, Chen Hao

Abstract excerpt

The Spontaneously Hypertensive Rat (SHR) is a widely used model for hypertension and, more recently, for neuropsychiatric disorders such as ADHD and Substance Use Disorder (SUD). Despite a common origin, SHR substrains from different vendors exhibit distinct behavioral phenotypes, particularly in models of SUD. This study characterizes the genomic landscape of two such substrains, SHR/NCrl and SHR/NHsd, using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41428022
DOI: 10.1007/s00335-025-10187-z
PMCID: PMC12722307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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