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Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory

1 Oct 2012

Abstract excerpt

One component of memory in the antibody system is long-lived memory B cells selected for the expression of somatically mutated, high-affinity antibodies in the T cell-dependent germinal center (GC) reaction. A puzzling observation has been that the memory B cell compartment also contains cells expressing unmutated, low-affinity antibodies. Using conditional Bcl6 ablation, we demonstrate that these cells are...

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PMID: 23027924
DOI: 10.1084/jem.20120127

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