Article

High-affinity, neutralizing antibodies to SARS-CoV-2 can be made in the absence of T follicular helper cells

2021-06-11

Abstract excerpt

T follicular helper (Tfh) cells are the conventional drivers of protective, germinal center (GC)-based antiviral antibody responses. However, loss of Tfh cells and GCs has been observed in patients with severe COVID-19. As T cell-B cell interactions and immunoglobulin class switching still occur in these patients, non-canonical pathways of antibody production may be operative during SARS-CoV-2 infection. We found...

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Literature Corpus work: 94f27100-b7dc-5734-8ebb-1eb3611d62cf
DOI: 10.1101/2021.06.10.447982

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