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Article

Self-Reactive B Cells in the Germinal Center Reaction

22 Jan 2018

Abstract excerpt

Maintenance of immunological self-tolerance requires lymphocytes carrying self-reactive antigen receptors to be selectively prevented from mounting destructive or inflammatory effector responses. Classically, self-tolerance is viewed in terms of the removal, editing, or silencing of B and T cells that have formed self-reactive antigen receptors during their early development. However, B cells activated by foreign...

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PMID: 29356584
DOI: 10.1146/annurev-immunol-051116-052510

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