Article
Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation.
Immunity - 23 Jul 2010
Garin Alexandre, Meyer-Hermann Michael, Contie Mathias, Figge Marc Thilo, Buatois Vanessa, Gunzer Matthias, Toellner Kai-Michael, Elson Greg, Kosco-Vilbois Marie H
Abstract excerpt
Germinal centers (GCs) are specialized microenvironments where antigen-activated B cells undergo proliferation, immunoglobulin (Ig) class switch recombination, somatic hypermutation (SHM), and affinity maturation. Within GCs, follicular dendritic cells (FDCs) are key players in driving these events via direct interaction with GC B cells. Here, we provide in vivo evidence that FDCs express and upregulate...
Topics
- Animals
- Antibodies, Blocking
- Antibody Affinity
- Antigens, Differentiation
- B-Lymphocytes
- Bone Marrow Transplantation
- Cell Differentiation
- Dendritic Cells, Follicular
- Germinal Center
- Immunoglobulin Class Switching
- Immunologic Memory
- Ligands