Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcription Factor T-bet in B Cells Modulates Germinal Center Polarization and Antibody Affinity Maturation in Response to Malaria.

Cell reports - 19 Nov 2019

Ly Ann, Liao Yang, Pietrzak Halina, Ioannidis Lisa J, Sidwell Tom, Gloury Renee, Doerflinger Marcel, Triglia Tony, Qin Raymond Z, Groom Joanna R, Belz Gabrielle T, Good-Jacobson Kim L, Shi Wei, Kallies Axel, Hansen Diana S

Abstract excerpt

Despite the key role that antibodies play in protection, the cellular processes mediating the acquisition of humoral immunity against malaria are not fully understood. Using an infection model of severe malaria, we find that germinal center (GC) B cells upregulate the transcription factor T-bet during infection. Molecular and cellular analyses reveal that T-bet in B cells is required not only for IgG2c switching...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibody Affinity
Share to B-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germinal Center

Share to Malaria

Share to Receptors, CXCR3

Share to RGS Proteins

Share to T-bet Transcription Factor

Share to T-Box Domain Proteins

Source

Identifiers

PMID: 31747599
DOI: 10.1016/j.celrep.2019.10.087

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcription Factor T-bet in B Cells Modulates Germinal Center Polarization and Antibody Affinity Maturation in Response to Malaria.PMID 31747599Read ↗

High-dimensional mass cytometry identifies T cell and B cell signatures predicting reduced risk of Plasmodium vivax malariaSemantic proximity Read ↗

A Germinal Center–Independent Innate-Like Memory B Cell Compartment of B1 OriginSemantic proximity Read ↗

Maturation Trajectories and Transcriptional Landscape of Plasmablasts and Autoreactive B Cells in COVID-19Semantic proximity Read ↗

Overexpression of T-bet in HIV infection is associated with accumulation of B cells outside germinal centers and poor affinity maturation.Semantic proximity Read ↗

The Differentiation in vitro of Human Tonsil B Cells With the Phenotypic and Functional Characteristics of T-bet+ Atypical Memory B Cells in MalariaSemantic proximity Read ↗

Gut Microbiota Composition Modulates the Magnitude and Quality of Germinal Centers during Plasmodium InfectionsSemantic proximity Read ↗

CD24 and CD27 resolve ontogeny and gradual differentiation of CD11c+ atypical memory B cells after malaria infectionSemantic proximity Read ↗

CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity.Semantic proximity Read ↗

Continuous germinal center invasion contributes to the diversity of the immune responseSemantic proximity Read ↗

Atypical B cells are a normal component of immune responses to vaccination and infection in humansSemantic proximity Read ↗

System-Level Scenarios for the Elucidation of T Cell-Mediated Germinal Center B Cell Differentiation.Semantic proximity Read ↗

PRDM1 shapes germinal center B-cell clonal diversity by gating chromatin accessibility during light-to-dark zone transitionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.