Article

Type I interferons promote germinal centers through B cell intrinsic signaling and dendritic cell dependent Th1 and Tfh cell lineages

2020-11-21

Abstract excerpt

Type I interferons (IFNs) play an essential role in antiviral immunity, correlate with severity of systemic autoimmune disease, and are likely to represent a key component of mRNA vaccine-adjuvanticity. Relevant to all, type I IFNs can enhance germinal center (GC) B cell responses but underlying signaling pathways are incompletely understood due to pleiotropic effects in multiple cell types. Here, we demonstrate t...

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Literature Corpus work: fa451f9e-680a-55f0-8e21-a4fd1a0a2ef4
DOI: 10.1101/2020.11.20.390625

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