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Article

B cell-intrinsic TLR7 signaling is essential for the development of spontaneous germinal centers.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2014

Soni Chetna, Wong Eric B, Domeier Phillip P, Khan Tahsin N, Satoh Takashi, Akira Shizuo, Rahman Ziaur S M

Abstract excerpt

Spontaneous germinal center (Spt-GC) B cells and follicular helper T cells generate high-affinity autoantibodies that are involved in the development of systemic lupus erythematosus. TLRs play a pivotal role in systemic lupus erythematosus pathogenesis. Although previous studies focused on the B cell-intrinsic role of TLR-MyD88 signaling on immune activation, autoantibody repertoire, and systemic inflammation,...

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Topics

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Share to Antibody Formation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25252960
DOI: 10.4049/jimmunol.1401720
PMCID: PMC4201954

Genes

TLR7
TLR9
TLR2
TLR3
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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