Back to search

Article

Impact of cross-ancestry genetic architecture on GWAS in admixed populations

2023-01-24

Abstract excerpt

Genome-wide association studies (GWAS) have identified thousands of variants for disease risk. These studies have predominantly been conducted in individuals of European ancestries, which raises questions about their transferability to individuals of other ancestries. Of particular interest are admixed populations, usually defined as populations with recent ancestry from two or more continental sources. Admixed ge...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
2be12e33-0aa0-5d0d-bd18-b422b30fdd7f
DOI
10.1101/2023.01.20.524946
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Impact of cross-ancestry genetic architecture on GWAS in admixed populationsDOI 10.1101/2023.01.20.524946
Impact of cross-ancestry genetic architecture on GWASs in admixed populations.Semantic proximity
Causal effects on complex traits are similar across segments of different continental ancestries within admixed individualsSemantic proximity
Causal effects on complex traits are similar across segments of different continental ancestries within admixed individualsSemantic proximity
Leveraging local ancestry and cross-ancestry genetic architecture to improve genetic prediction of complex traits in admixed populations.Semantic proximity
Admixed and single-continental genome segments of the same ancestry have distinct linkage disequilibrium patterns.Semantic proximity
Admixed Populations Improve Power for Variant Discovery and Portability in Genome-wide Association StudiesSemantic proximity
Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals.Semantic proximity
On Using Local Ancestry to Characterize the Genetic Architecture of Human Phenotypes: Genetic Regulation of Gene Expression in Multiethnic or Admixed Populations as a ModelSemantic proximity
Evaluating Multi-Ancestry Genome-Wide Association Methods: Statistical Power, Population Structure, and Practical ImplicationsSemantic proximity
Ancestry-specific association mapping in admixed populationsSemantic proximity
Evaluating multi-ancestry genome-wide association methods: Statistical power, population structure, and practical implications.Semantic proximity
AdmixPower: Statistical Power and Sample Size Estimation for Mapping Genetic Loci in Admixed Populations.Semantic proximity
Select a neighboring publication to make it the new centre.